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Migrants, especially those in temporary accommodations like camps and shelters, might be a vulnerable population during the COVID-19 pandemic, but little is known about the impact of the pandemic in these settings in low-income and middle-income countries. The authors assessed SARS-CoV-2 seropositivity and RNA prevalence, the correlates of seropositivity (emphasizing socially determined conditions), and the socioeconomic impacts of the pandemic among migrants living in shelters in Tijuana, a city on the Mexico-U.S. border.