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Grayson's theoretically and methodologically sophisticated analyses of vertebrate remains from archaeological and paleontological sites has insights to questions of adaptive and subsistence change (and continuity) among early humans both in the Old World and the New. His work focuses on past environments and their influence on humans, and the impact of humans on ancient environments. Beyond his contributions to understanding human and environmental prehistory, he is noted for his role in finding the application of formal and quantitative methods to the analysis of animal bones recovered from archaeological deposits. In 2005, Grayson was awarded the Nevada Medal by the Desert Research Institute. He was elected into the National Çï¿ûÊÓƵ of Sciences in 2011 and received the Lifetime Achievement Award from the Great Basin Anthropological Association in 2012..