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Diane Griffin teaches in the Department of Molecular Microbiology and Immunology at the Bloomberg School at Johns Hopkins University. She has a joint appointment at the School of Medicine, where she serves as professor of infectious diseases and of neurology.

Griffin's research focuses on how viruses cause disease and how immunity leads to both recovery and protection from reinfection. Her team is currently investigating how measles virus infection suppresses the immune system.

She was also the founding director of the Johns Hopkins Malaria Research Institute and past president of the American Society for Virology, the Association of Medical School Microbiology Chairs and the American Society for Microbiology.